The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

Post-translational modifications (PTMs) create vast structural and functional diversity of
proteins, ultimately modulating protein function and degradation, influencing cellular …

Post-translational modifications (PTMs) on intact histones play a major role in regulating
chromatin dynamics and influence biological processes such as DNA transcription …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

Top-down protein mass spectrometry can provide unique insights into protein sequence and
structure, including precise proteoform identification and study of protein–ligand and protein …

193 nm ultraviolet photodissociation (UVPD) allows high sequence coverage to be obtained
for intact proteins using terminal fragments alone. However, internal fragments, those that …

“Top-down” proteomics analyzes intact proteins and identifies proteoforms by their intact
mass as well as the observed fragmentation pattern in tandem mass spectrometry (MS/MS) …

Studies of large proteins, protein complexes, and membrane protein complexes pose new
challenges, most notably the need for increased ion mobility (IM) and mass spectrometry …

Trapped ion mobility spectrometry (TIMS) when coupled with mass spectrometry (MS) offers
great advantages for the separation of isobaric, isomeric, and/or conformeric species. In the …

Obtaining extensive sequencing of an intact protein is essential in order to simultaneously
determine both the nature and exact localization of chemical and genetic modifications …