Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

A long-standing association exists between elevated triglyceride levels and cardiovascular
disease*(CVD). 1, 2 However, the extent to which triglycerides directly promote CVD or …

Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against
cold, and has recently been shown to be present in humans,,. Triglyceride-rich lipoproteins …

Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

BACKGROUND: Whether triglyceride-mediated pathways are causally relevant to coronary
heart disease is uncertain. We studied a genetic variant that regulates triglyceride …

Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such …

Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several
studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; …

In patients with diabetes, an increased risk of symptomatic heart failure usually develops in
the presence of hypertension or ischemic heart disease. However, a predisposition to heart …

FGF21 decreases plasma triglycerides (TGs) in rodents and humans; however, the
underlying mechanism or mechanisms are unclear. In the present study, we examined the …