Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …
Targeted deletion of PD-1 in myeloid cells induces antitumor immunity
PD-1, a T cell checkpoint receptor and target of cancer immunotherapy, is also expressed on
myeloid cells. The role of myeloid-specific versus T cell–specific PD-1 ablation on antitumor …
myeloid cells. The role of myeloid-specific versus T cell–specific PD-1 ablation on antitumor …
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
Fructose intake has increased substantially throughout the developed world and is
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …
Endocrine role of bone in the regulation of energy metabolism
R Zhou, Q Guo, Y ** and genetic engineering, as well as the advent of single cell RNA …
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy
Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …
[HTML][HTML] mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
Necrosis of macrophages in the granuloma, the hallmark immunological structure of
tuberculosis, is a major pathogenic event that increases host susceptibility. Through a …
tuberculosis, is a major pathogenic event that increases host susceptibility. Through a …
[HTML][HTML] Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer
J Zeng, WKK Wu, H Wang, X Li - Pharmacological Research, 2019 - Elsevier
Mammalian/mechanistic target of rapamycin (mTOR) is a critical sensor of environmental
cues that regulates cellular macromolecule synthesis and metabolism in eukaryotes. DNA …
cues that regulates cellular macromolecule synthesis and metabolism in eukaryotes. DNA …