The placenta serves as the interface between the maternal and fetal circulations and
regulates the transfer of oxygen, nutrients, and waste products. When exogenous …

Cytochrome P450 aromatase (AROM) and steroid sulfatase (STS) are the two key enzymes
for the biosynthesis of estrogens in human, and maintenance of the critical balance between …

Polychlorinated biphenyls (PCBs) are persistent organic toxicants derived from legacy
pollution sources and their formation as inadvertent byproducts of some current …

Abstract Human placental estrone (E1)/dehydroepiandrosterone (DHEA) sulfatase (human
placental steroid sulfatase; hSTS) is an integral membrane protein of the endoplasmic …

Despite the extensive research during the last six decades the fundamental questions
concerning the role of steroids in the initiation of human parturition and origin and function of …

Steroid hormones often circulate in the plasma as inactive sulfated forms, such as estrone
sulfate and dehydroepiandrosterone sulfate. The enzyme steroid sulfatase (STS) converts …

Estrogens are closely involved in the development of hormone-dependent carcinomas.
Estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase …

Objective To evaluate, in peritoneal, ovarian, and rectovaginal endometriotic lesions,
expression of steroidogenic enzymes involved in the activation and inactivation of …

Progesterone and estradiol are the foremost steroid hormones in human pregnancy.
However, the origin of maternal progesterone has still not been satisfactorily explained …

In this article we show that 1α, 25-dihydroxyvitamin D3 (1α, 25 (OH) 2D3) stimulates the
activity of the class IA phosphatidylinositol 3-kinase PI3Kα and its downstream target Akt in …