Immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome is a
rare disorder that increasingly has gained attention as a model of genetic autoimmunity …

The transcription factor Foxp3 controls the differentiation and function of regulatory T‐cells
(Treg). Studies in the past decades identified numerous Foxp3‐interacting protein partners …

Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central
orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in …

The prototypical genetic autoimmune disease is immune dysregulation polyendocrinopathy
enteropathy X-linked (IPEX) syndrome, a severe pediatric disease with limited treatment …

Cell-based therapies for autoimmune diseases have gained significant traction, with several
approaches centered around the regulatory T (Treg) cell─ a well-known …

Background Systemic sclerosis (SSc) is an autoimmune disorder characterized by fibrosis of
the skin and internal organs. Pathologic conversion of regulatory T (Treg) cells into …

In the past two decades, a significant number of studies have been published describing the
molecular and clinical aspects of Immune dysregulation Polyendocrinopathy Enteropathy X …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Regulatory T cells (Tregs) control immune homeostasis and prevent exacerbated immune
responses, and can be used as cell therapy to dampen a variety of autoimmune or …

In the quest for more precise and effective organ transplantation therapies, chimeric antigen
receptor (CAR) regulatory T cell (T reg) therapies represent a potential cutting-edge …