Drug repurposing for COVID-19: Approaches, challenges and promising candidates

YL Ng, CK Salim, JJH Chu - Pharmacology & therapeutics, 2021 - Elsevier
Traditional drug development and discovery has not kept pace with threats from emerging
and re-emerging diseases such as Ebola virus, MERS-CoV and more recently, SARS-CoV …

Molecular mechanisms and therapeutic target of NETosis in diseases

J Huang, W Hong, M Wan, L Zheng - MedComm, 2022 - Wiley Online Library
Evidence shows that neutrophils can protect the host against pathogens in multiple ways,
including the formation and release of neutrophil extracellular traps (NETs). NETs are web …

Hydroxychloroquine in COVID-19: potential mechanism of action against SARS-CoV-2

S Satarker, T Ahuja, M Banerjee, VB E, S Dogra… - Current pharmacology …, 2020 - Springer
Abstract Purpose of Review The rapid spread of virus, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has turned out to be a global emergency. Symptoms of this …

Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019

P Bansal, A Goyal, A Cusick Iv, S Lahan… - Annals of …, 2021 - Taylor & Francis
Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and
anti-inflammatory agent for the management of autoimmune and rheumatic diseases such …

Inhibition of NETosis for treatment purposes: friend or foe?

TM Chamardani, S Amiritavassoli - Molecular and Cellular Biochemistry, 2022 - Springer
Active neutrophils participate in innate and adaptive immune responses through various
mechanisms, one of the most important of which is the formation and release of neutrophil …

Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies

PM Varghese, AG Tsolaki, H Yasmin, A Shastri… - Immunobiology, 2020 - Elsevier
The current coronavirus pandemic, COVID-19, is the third outbreak of disease caused by the
coronavirus family, after Severe Acute Respiratory Syndrome and Middle East Respiratory …

Distance based and bond additive topological indices of certain repurposed antiviral drug compounds tested for treating COVID‐19

JB Liu, M Arockiaraj, M Arulperumjothi… - International Journal of …, 2021 - Wiley Online Library
The entire world is struggling to control the spread of coronavirus (COVID‐19) as there are
no proper drugs for treating the disease. Under clinical trials, some of the repurposed …

[HTML][HTML] Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

C Jiang, X Yao, Y Zhao, J Wu, P Huang, C Pan… - Microbes and …, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to sweep the
world, causing infection of millions and death of hundreds of thousands. The respiratory …

[HTML][HTML] COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor

EL Feitosa, FTDSS Júnior, JADON Neto… - … journal of medical …, 2020 - ncbi.nlm.nih.gov
The SARS-CoV-2 spread quickly across the globe. The World Health Organization (WHO)
on March 11 declared COVID-19 a pandemic. The mortality rate, hospital disorders and …

National registry for patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 in Germany (ReCoVery): a valuable mean to gain rapid and …

R Hasseli, U Mueller-Ladner, T Schmeiser… - RMD open, 2020 - rmdopen.bmj.com
Objectives Patients with inflammatory rheumatic diseases (IRD) infected with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) may be at risk to develop a severe …