Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

H Ohtsuka, T Shimasaki, H Aiba - Advanced Biology, 2024 - Wiley Online Library
Yeast is an excellent model organism for research for regulating aging and lifespan, and the
studies have made many contributions to date, including identifying various factors and …

Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential

A Fuerlinger, A Stockner, S Sedej… - Cardiovascular …, 2025 - Springer
The global increase in human life expectancy, coupled with an unprecedented rise in the
prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart …

Senotherapeutic Peptide 14 Suppresses Th1 and M1 Human T Cell and Monocyte Subsets In Vitro

T Alencar-Silva, SM Barcelos, A Silva-Carvalho… - Cells, 2024 - mdpi.com
Inflammation contributes to the onset and exacerbation of numerous age-related diseases,
often manifesting as a chronic condition during aging. Given that cellular senescence fosters …

TOR2 plays the central role in rapamycin-induced lifespan extension in budding yeast

D Seo, G Yalcin, H Jang, HJ Lee, DH Kim… - … and biophysical research …, 2024 - Elsevier
The target of rapamycin (TOR) protein, renowned for its highly conserved nature across
species, plays a pivotal role in modulating signaling pathways via its multiprotein …