Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to
its success for hematological malignancies in clinical studies leading to the US Food and …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …

We explored the utility of targeting anaplastic lymphoma kinase (ALK), a cell surface
receptor overexpressed on pediatric solid tumors, using chimeric antigen receptor (CAR) …

Chimeric antigen receptor (CAR) T cell therapies targeting single antigens have performed
poorly in clinical trials for solid tumors due to heterogenous expression of tumor-associated …

With immunotherapy innovations for cancer treatment, in particular chimeric antigen receptor
(CAR) T cells, becoming more successful and prevalent, strategies to mitigate and manage …

We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-
surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target …

Patients with high risk neuroblastoma have a poor prognosis and survivors are often left with
debilitating long term sequelae from treatment. Even after integration of anti-GD2 …

Background Glypican 2 (GPC2), a member of glypican (GPC) family genes, produces
proteoglycan with a glycosylphosphatidylinositol anchor. It has shown its ascending …

Glypicans are a group of cell-surface glycoproteins in which heparan sulfate (HS)
glycosaminoglycan chains are covalently linked to a protein core. The glypican gene family …

Background Standard-of-care therapies for treating pediatric medulloblastoma have long-
term side effects, even in children who are cured. One emerging modality of cancer therapy …