Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …

An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …

Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are
able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and lipid-gating …

The transient receptor potential canonical type 3 (TRPC3) channel plays a pivotal role in
regulating neuronal excitability in the brain via its constitutive activity. The channel is …

In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …

Abstract Alzheimer's disease (AD), the most common form of dementia in the elderly, has no
cure. Thus, the identification of key molecular mediators of cognitive decline in AD remains a …

Plasticity of intrinsic neuronal excitability facilitates learning and memory across multiple
species, with aberrant modulation of this process being linked to the development of …

TRPC3 is one of the classical members of the mammalian transient receptor potential (TRP)
superfamily of ion channels. TRPC3 is a molecule with intriguing sensory features including …

Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons
that express calcium (Ca2+)-activated nonselective cationic current (I CAN) to generate …