Drug delivery applications of chitin and chitosan: a review

R Parhi - Environmental Chemistry Letters, 2020 - Springer
Polymers are used in drug delivery devices for drug encapsulation and release. Natural
polymers often have advantages such as biocompatibility, biodegradability and biologically …

Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems

AZ Alkilani, J Nasereddin, R Hamed, S Nimrawi… - Pharmaceutics, 2022 - mdpi.com
The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms
but is as convenient and easy to use for the patient as oral solid dosage forms. In recent …

Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?

C Gorzelanny, C Mess, SW Schneider, V Huck… - Pharmaceutics, 2020 - mdpi.com
Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery

J Li, B Liu, Y Zhou, Z Chen, L Jiang, W Yuan, L Liang - PLoS One, 2017 - journals.plos.org
Microneedle arrays (MA) have been extensively investigated in recent decades for
transdermal drug delivery due to their pain-free delivery, minimal skin trauma, and reduced …

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products

R Parhi, A Mandru - Drug delivery and translational research, 2021 - Springer
Traditionally, the skin is considered as a protective barrier which acts as a highly
impermeable region of the human body. But in recent times, it is recognized as a specialized …

Rapidly separating microneedles for transdermal drug delivery

DD Zhu, QL Wang, XB Liu, XD Guo - Acta biomaterialia, 2016 - Elsevier
The applications of polymer microneedles (MNs) into human skin emerged as an alternative
of the conventional hypodermic needles. However, dissolving MNs require many minutes to …

Dissolving microneedle arrays with optimized needle geometry for transcutaneous immunization

Y Li, X Hu, Z Dong, Y Chen, W Zhao, Y Wang… - European Journal of …, 2020 - Elsevier
In this study, the feasibility of transcutaneous immunization using different needle-
geometries dissolving microneedle array (DMNA) were investigated as drug carriers for …

Recent advances in 3D printed microneedles and their skin delivery application in the treatment of various diseases

R Parhi - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Microneedle (MN) has got ever-increasing attention from researchers and clinics because it
combined the advantages of both the transdermal route the and parenteral route. As a result …

Recent advances in microneedle designs and their applications in drug and cosmeceutical delivery

R Parhi - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Transdermal drug delivery (TDD) was initially limited to fewer therapeutic agents due to the
requirements of suitable physicochemical and biological properties for passage across the …

Nanostructure-Mediated Transport of Therapeutics through Epithelial Barriers

ME Hansen, Y Ibrahim, TA Desai, M Koval - International journal of …, 2024 - mdpi.com
The ability to precisely treat human disease is facilitated by the sophisticated design of
pharmacologic agents. Nanotechnology has emerged as a valuable approach to creating …