Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem.
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …

This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Sažetak Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents
(NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter …

A library of 14 mono-oxime quinuclidinium-based compounds with alkyl or benzyl
substituent were synthesized and characterized in vitro as potential antidotes for …

Nerve agents, the deadliest chemical warfare agents, are potent inhibitors of
acetylcholinesterase (AChE) and cause rapid cholinergic crisis with serious symptoms of …

Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-
positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes …

A well-considered treatment of acute nerve agents poisoning involves the exogenous
administration of butyrylcholinesterase (BChE, EC 3.1. 1.8) as a stoichiometric bioscavenger …

Sažetak We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-
hydroxyimino methylpyridinium)-but-2-ene dibromide] with tabun-inhibited human …

Butyrylcholinesterase is considered to be an endogenous stoichiometric bioscavenger of
organophosphorus compounds (OPs), but due to limited concentration of BChE in the …

Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine,
when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents …