Mammary gland development: cell fate specification, stem cells and the microenvironment
The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …
Mammary stem cells and the differentiation hierarchy: current status and perspectives
JE Visvader, J Stingl - Genes & development, 2014 - genesdev.cshlp.org
The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …
Cancer stem cell definitions and terminology: the devil is in the details
The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …
investigation has been hampered both by a lack of consistency in the terms used for these …
N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties
N-cadherin and HER2/neu were found to be co-expressed in invasive breast carcinomas. To
test the contribution of N-cadherin and HER2 in mammary tumor metastasis, we targeted N …
test the contribution of N-cadherin and HER2 in mammary tumor metastasis, we targeted N …
Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium
F Meier-Abt, E Milani, T Roloff, H Brinkhaus… - Breast Cancer …, 2013 - Springer
Introduction Early pregnancy has a strong protective effect against breast cancer in humans
and rodents, but the underlying mechanism is unknown. Because breast cancers are …
and rodents, but the underlying mechanism is unknown. Because breast cancers are …
Isolation of mouse and human tumor-associated macrophages
L Cassetta, R Noy, A Swierczak, G Sugano… - Tumor …, 2016 - Springer
The tumor microenvironment is a complex network of cells that support tumor progression
and malignancy. It has been demonstrated that tumor cells can educate the immune system …
and malignancy. It has been demonstrated that tumor cells can educate the immune system …
PKA signaling drives mammary tumorigenesis through Src
Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however,
its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA …
its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA …
RUNX2 in mammary gland development and breast cancer
N Ferrari, L McDonald, JS Morris… - Journal of cellular …, 2013 - Wiley Online Library
Runx2 is best known as an essential factor in osteoblast differentiation and bone
development but, like many other transcription factors involved in development, is known to …
development but, like many other transcription factors involved in development, is known to …
How pregnancy at early age protects against breast cancer
F Meier-Abt, M Bentires-Alj - Trends in molecular medicine, 2014 - cell.com
Pregnancy at an early age has a strong protective effect against breast cancer in humans
and rodents. Postulated mechanisms underlying this phenomenon include alterations in the …
and rodents. Postulated mechanisms underlying this phenomenon include alterations in the …
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells
C Priami, D Montariello, G De Michele… - Cell Death & …, 2022 - nature.com
Aging is accompanied by the progressive decline in tissue regenerative capacity and
functions of resident stem cells (SCs). Underlying mechanisms, however, remain unclear …
functions of resident stem cells (SCs). Underlying mechanisms, however, remain unclear …