MAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and
intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element …

Oxygen tolerance of anaerobes is a virulence factor, but can also be a beneficial property.
Many species have evolved to tolerate or take advantage of the presence of low, especially …

Leveraging systems biology approaches, we illustrate how metabolically distinct species of
Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating …

Clostridioides difficile, the major cause of antibiotic-associated diarrhea, is a strict anaerobic,
sporulating Firmicutes. However, during its infectious cycle, this anaerobe is exposed to low …

Clostridia comprise bacteria of environmental, biotechnological and medical interest and
many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen …

Clostridioides difficile causes a serious diarrheal disease and is a common healthcare-
associated bacterial pathogen. Although it has a major impact on human health, the …

Much of our current knowledge about cellular RNA–protein complexes in bacteria is derived
from analyses in gram-negative model organisms, with the discovery of RNA-binding …

Clostridioides difficile is a major cause of diarrhea associated with antibiotherapy. After
germination of C. difficile spores in the small intestine, vegetative cells are exposed to low …

Highlights•Low oxygen tensions are present throughout the gastrointestinal tract.•Although
Clostridioides difficile is considered as obligate anaerobe, this bacterium can tolerate low …

Antibiotic resistance is one of the world's greatest public health challenges and adjunct
probiotic therapies are strategies that could lessen this burden. Clostridioides difficile …