Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

The development of tyrosinase inhibitors to prevent the enzymatic browning have become a
research hotspot in food industry. 4-Hydroxycinnamic acid (CA) and ferulic acid (FA) are …

Cancer represents the main cause of morbidity and mortality worldwide, constituting a
serious health problem. In this context, melanoma represents the most aggressive and fatal …

The structure of extracted condensed tannin (CT) from the fruit of Sour jujube (Ziziphus
jujuba Mill. var. spinosa (Bunge) Hu ex HF Chow) and the molecular mechanisms by which …

Tyrosinase plays a central role in the biosynthesis pathway of melanin pigment and its
activity has also been linked to Parkinson's and other neurodegenerative diseases. Melanin …

Melanogenesis produces human melanin, which protects against UV radiation but can lead
to skin issues and severe cancers if not appropriately regulated. The enzyme tyrosinase …

Chromenes are compounds that may be useful for inhibiting topoisomerase and
cytochrome, enzymes involved in the growth of cancer and fungal cells, respectively. The …

Tyrosinase is the central enzyme involved in the highly complex process of melanin
formation, catalyzing the rate-limiting steps of this biosynthetic pathway. Due to such a …

The three-dimensional structure of tyrosinase has been crystallized from many species but
not from Homo sapiens. Tyrosinase is a key enzyme in melanin biosynthesis, being an …

Tyrosinases belong to the functional copper-containing proteins family, and their structure
contains two copper atoms, in the active site, which are coordinated by three histidine …