Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

The emerging antioxidant paradigm of mesenchymal stem cell therapy

R Stavely, K Nurgali - Stem Cells Translational Medicine, 2020 - academic.oup.com
Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for
the treatment of diverse diseases, with many promising outcomes achieved in animal …

Targeting angiogenesis and lymphangiogenesis in kidney disease

K Tanabe, J Wada, Y Sato - Nature Reviews Nephrology, 2020 - nature.com
The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …

Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases

W Zhang, T Wang, Y Xue, B Zhan, Z Lai… - Frontiers in …, 2023 - frontiersin.org
There is growing evidence that mesenchymal stem cell-derived extracellular vesicles and
exosomes can significantly improve the curative effect of oxidative stress-related diseases …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles to the rescue of renal injury

L Birtwistle, XM Chen, C Pollock - International Journal of Molecular …, 2021 - mdpi.com
Acute kidney injury (AKI) and chronic kidney disease (CKD) are rising in global prevalence
and cause significant morbidity for patients. Current treatments are limited to slowing instead …

Potential and therapeutic efficacy of cell-based therapy using mesenchymal stem cells for acute/chronic kidney disease

CW Yun, SH Lee - International journal of molecular sciences, 2019 - mdpi.com
Kidney disease can be either acute kidney injury (AKI) or chronic kidney disease (CKD) and
it can lead to the development of functional organ failure. Mesenchymal stem cells (MSCs) …

Mesenchymal stem cell-derived extracellular vesicles in tissue regeneration

B Zhang, X Tian, J Hao, G Xu… - Cell transplantation, 2020 - journals.sagepub.com
Mesenchymal stem cells (MSCs) are multipotent stem cells that have attracted increasing
interest in the field of regenerative medicine. Previously, the differentiation ability of MSCs …

[HTML][HTML] Understanding molecular characteristics of extracellular vesicles derived from different types of mesenchymal stem cells for therapeutic translation

Z Ding, ZF Greenberg, MF Serafim, S Ali… - Extracellular vesicle, 2024 - Elsevier
Mesenchymal stem cells (MSCs) have been studied for decades as candidates for cellular
therapy, and their secretome, including secreted extracellular vesicles (EVs), has been …

Conditioned medium of mesenchymal stromal cells: a new class of therapeutics

NV Bogatcheva, ME Coleman - Biochemistry (Moscow), 2019 - Springer
Mesenchymal stromal cell (MSCs) represent a class of biologics with the prospects for
employment as immunomodulatory, tissue-protective, and regenerative therapeutics. In …