In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-
dimensional models of the whole human proteome to the scientific community. Here we …

Components of transcriptional machinery are selectively partitioned into specific
condensates, often mediated by protein disorder, yet we know little about how this specificity …

Protein structures can provide invaluable information, both for reasoning about biological
processes and for enabling interventions such as structure-based drug development or …

Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA nucleotide modification
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to …

Intrinsically disordered proteins and protein regions (IDPs/IDRs) carry out important
biological functions without relying on a single well-defined conformation. As these proteins …

Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …