REVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized
machinery. The central component of this machinery is a proteolytic system involving a …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Caspases are a family of cysteine proteases that play important roles in regulating
apoptosis. A decade of research has generated a wealth of information on the signal …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

The principal pathological features of Alzheimer's disease (AD) are extracellular amyloid
plaques and intracellular neurofibrillary tangles, the latter composed of the microtubule …

Apoptosis or programmed cell death (PCD) is a genetically regulated, cellular suicide
mechanism that plays a crucial role in development and in the defense of homeostasis …

It is now generally accepted that protein phosphorylation-dephosphorylation has a role in
the regulation of essentially all cellular functions. Thus, it is of interest that this process is …

Neurons are an unusual type of cell in that they send processes (axons and dendrites) over
great distances. This elaborate morphology, together with their excitability, places neurons …

Caspases are key mediators of apoptosis. Using a novel expression cloning strategy we
recently developed to identify cDNAs encoding caspase substrates, we isolated the …