The control of ion transport and homeostasis is a critical function of living organisms. In this
perspective, an overview of different synthetic systems capable of facilitating the …

The progress of the pillar [5] arene chemistry allowed us to set out a new concept on
application of the supramolecular assemblies to create antimicrobial films with variable …

Synthetic and natural ionophores have been developed to catalyze ion transport and have
been shown to exhibit a variety of biological effects. We synthesized 24 aza-and diaza …

A series of previously unknown aromatic polyether macrodiolides containing a cis, cis-1, 5-
diene moiety in the molecule were synthesized in 47–74% yields. Macrocycle compounds …

P-glycoprotein (P-gp, MDR1) is a promiscuous drug efflux pump of substantial
pharmacological importance. Taking advantage of large-scale cytotoxicity screening data …

Multidrug resistance (MDR) is a widespread phenomenon exhibited by many cancers and
represents a fundamental obstacle for successful cancer treatments. Tumour cells commonly …

A series of novel N-1-monoallylated 2, 5-diketopiperazine derivatives were designed,
synthesized, and evaluated as cytotoxic agents against eight cancer cell lines by using …

Comprehensive resource on an important and fascinating compound class, covering
synthesis, properties, functionalization, and applications in organic synthesis, materials …

A set of crown ethyl acyl derivatives based on 18-crown-6 moiety was synthesized and
evaluated for biological activity. In vitro antiproliferative profiling demonstrated significant …

Overexpression of ABC transporters, such as ABCB1 and ABCG2, plays an important role in
mediating multidrug resistance (MDR) in cancer. This feature is also attributed to a …