Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

Globally, Alzheimer's disease (AD) is the most widespread chronic neurodegenerative
disorder, leading to cognitive impairment, such as aphasia and agnosia, as well as mental …

Aggregation of tau protein into intracellular fibrillary inclusions is characterized as the
hallmark of tauopathies, including Alzheimer's disease and chronic traumatic …

The escalating prevalence of Alzheimer's disease (AD) highlights the urgent need to
develop reliable biomarkers for early diagnosis and intervention. AD is characterized by the …

Tau is an intrinsically disordered (IDP) microtubule-associated protein (MAP) that plays a
key part in microtubule assembly and organization. The function of tau can be regulated by …

The aggregation of RNA binding proteins, including hnRNPA1/2, TDP-43 and FUS, is
heavily implicated in causing or increasing disease risk for a series of neurodegenerative …

The pathogenesis of Alzheimer's disease (AD), a degenerative disease of the central
nervous system, remains unclear. The main manifestations of AD include cognitive and …

Protein aggregation is a widespread phenomenon implicated in debilitating diseases like
Alzheimer's, Parkinson's, and cataracts, presenting complex hurdles for the field of …

To propose new mechanism-based therapeutics for Alzheimer's disease (AD), it is crucial to
study the kinetics and oligomerization/aggregation mechanisms of the hallmark tau proteins …

Tau is a microtubule (MT)-associated protein that binds to and stabilizes the MTs of neurons.
Due to its intrinsically disordered nature, it undergoes several post-translational …