CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch
ES McCoy, B Taylor-Blake, MJ Zylka - PloS one, 2012 - journals.plos.org
Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of
nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what …
nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what …
RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose
Diabetes mellitus is associated with sensory abnormalities, including exacerbated
responses to painful (hyperalgesia) or non-painful (allodynia) stimuli. These abnormalities …
responses to painful (hyperalgesia) or non-painful (allodynia) stimuli. These abnormalities …
Peripheral μ-opioid receptor mediated inhibition of calcium signaling and action potential-evoked calcium fluorescent transients in primary afferent CGRP nociceptive …
While μ-opioid receptor (MOR) agonists remain the most powerful analgesics for the
treatment of severe pain, serious adverse side effects that are secondary to their central …
treatment of severe pain, serious adverse side effects that are secondary to their central …
Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres
The selective 5-HT1 receptor agonist sumatriptan is an effective therapeutic for migraine
pain yet the antimigraine mechanisms of action remain controversial. Pain-responsive fibres …
pain yet the antimigraine mechanisms of action remain controversial. Pain-responsive fibres …
Anaplastic meningioma with rapid growth after omental flap transposition: a case report and experimental study
K Iwami, H Momota, M Fujii, A Natsume, S Yagi… - Brain Tumor …, 2015 - Springer
Meningiomas occasionally display aggressive behavior, but the mechanisms of malignant
transformation remain unclear. We encountered the case of a 65-year-old man with a 10 …
transformation remain unclear. We encountered the case of a 65-year-old man with a 10 …
Optical assessment of nociceptive TRP channel function at the peripheral nerve terminal
F Aleixandre-Carrera, N Engelmayer… - International Journal of …, 2021 - mdpi.com
Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of
this, little is known about their functional organization. Transient receptor potential (TRP) …
this, little is known about their functional organization. Transient receptor potential (TRP) …
Ultrafast optical recording reveals distinct capsaicin-induced ion dynamics along single nociceptive neurite terminals in vitro
RH Goldstein, B Katz, S Lev… - Journal of Biomedical …, 2017 - spiedigitallibrary.org
Pain signals are detected by terminals of nociceptive peripheral fibers situated among the
keratinocytes and epithelial cells. Despite being key structures for pain-related stimuli …
keratinocytes and epithelial cells. Despite being key structures for pain-related stimuli …