Tissue destruction and invasion by Entamoeba histolytica

KS Ralston, WA Petri - Trends in parasitology, 2011‏ - cell.com
Entamoeba histolytica is the causative agent of amebiasis, a disease that is a major source
of morbidity and mortality in the develo** world. The potent cytotoxic activity of the parasite …

Regulation of Virulence of Entamoeba histolytica

C Marie, WA Petri Jr - Annual review of microbiology, 2014‏ - annualreviews.org
Entamoeba histolytica is the third-leading cause of parasitic mortality globally. E. histolytica
infection generally does not cause symptoms, but the parasite has potent pathogenic …

Self-generated chemoattractant gradients: attractant depletion extends the range and robustness of chemotaxis

L Tweedy, DA Knecht, GM Mackay, RH Insall - PLoS biology, 2016‏ - journals.plos.org
Chemotaxis is fundamentally important, but the sources of gradients in vivo are rarely well
understood. Here, we analyse self-generated chemotaxis, in which cells respond to …

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

AJ Muinonen-Martin, O Susanto, Q Zhang… - PLoS …, 2014‏ - journals.plos.org
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs
unusually early in tumour evolution. Unlike most solid tumours, thickness rather than …

Antiprotozoal activity of some medicinal plants against entamoeba histolytica, the causative agent of amoebiasis

CO Adetunji, OT Oyeyemi - … , biopharmaceutics, forensic science …, 2022‏ - taylorfrancis.com
The prevalence of amoebiasis disease caused by Entamoeba histolytica has been
highlighted as one of the major threats to human well-being and key public health …

Dynamic instability of the intracellular pressure drives bleb-based motility

B Maugis, J Brugués, P Nassoy… - Journal of cell …, 2010‏ - journals.biologists.com
We have demonstrated that the two-and three-dimensional motility of the human pathogenic
parasite Entamoeba histolytica (Eh) depends on sustained instability of the intracellular …

Characterization of extracellular vesicles from Entamoeba histolytica identifies roles in intercellular communication that regulates parasite growth and development

M Sharma, P Morgado, H Zhang… - Infection and …, 2020‏ - journals.asm.org
Extracellular vesicles (EVs) secreted by eukaryotic and prokaryotic cells to transport lipids,
proteins, and nucleic acids to the external environment have important roles in cell-cell …

Steering yourself by the bootstraps: how cells create their own gradients for chemotaxis

RH Insall, P Paschke, L Tweedy - Trends in Cell Biology, 2022‏ - cell.com
Chemotaxis, where cell movement is steered by chemical gradients, is a widespread and
essential way of organising cell behaviour. But where do the instructions come from–who …

[HTML][HTML] Virulence and virulence factors in Entamoeba histolytica, the agent of human amoebiasis

DM Faust, N Guillen - Microbes and infection, 2012‏ - Elsevier
Human infections with Entamoeba histolytica sporadically become pathogenic, unknown
triggers converting the parasite to its invasive phenotype. Parasite virulence results from …

Extracellular vesicles released by anaerobic protozoan parasites: Current situation

YR Nievas, A Lizarraga, N Salas… - Cellular …, 2020‏ - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a ubiquitous mechanism for transferring
information between cells and organisms across all three kingdoms of life. Parasitic …