Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

This report calls on the nation—its leaders, its mental health research and service provision
agencies, its schools, its primary care medical systems, its community-based organizations …

Ras oncoproteins play pivotal roles in both the development and maintenance of many
tumor types. Unfortunately, these proteins are difficult to directly target using traditional …

Summary Neurofibromatosis type 1 (NF1) is a familial tumour syndrome. Malignant tumours
can arise in the nervous and non-nervous system in either childhood or adulthood, with …

Malignant peripheral nerve sheath tumour (MPNST) is a rare malignancy accounting for 3–
10% of all soft tissue sarcomas. Most MPNSTs arise in association with peripheral nerves or …

Neurofibromatosis Type 1 (NF1) is a common genetic disorder and cancer predisposition
syndrome (1: 3000 births) caused by mutations in the tumor suppressor gene NF1. NF1 …

Statins are competitive inhibitors of 3‐hydroxy‐3‐methylyglutaryl‐coenzyme A reductase
and reduce low‐density lipoprotein‐C levels. Statins are well‐tolerated drugs used for …

Oncogenic Ras proteins are a driving force in a significant set of human cancers and
wildtype, unmutated Ras proteins likely contribute to the malignant phenotype of many more …

Despite significant, frequently very strong, antiproliferative and tumoricidal effects of statins
demonstrated in vitro, their antitumor effects in animal models are modest, and their efficacy …

Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-
14, and NF90-8 to nanomolar concentrations of both lovastatin and farnesyl transferase …