Understanding the connection between common stroke comorbidities, their associated inflammation, and the course of the cerebral ischemia/reperfusion cascade

Ł Przykaza - Frontiers in immunology, 2021 - frontiersin.org
Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

Angiogenesis in the infarcted myocardium

C Cochain, KM Channon, JS Silvestre - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Proangiogenic therapy appeared a promising strategy for the treatment of
patients with acute myocardial infarction (MI), as de novo formation of microvessels, has the …

Deregulation of microRNA-503 contributes to diabetes mellitus–induced impairment of endothelial function and reparative angiogenesis after limb ischemia

A Caporali, M Meloni, C Völlenkle, D Bonci… - Circulation, 2011 - Am Heart Assoc
Background—Diabetes mellitus impairs endothelial cell (EC) function and postischemic
reparative neovascularization by molecular mechanisms that are not fully understood …

[HTML][HTML] Tissue-engineered vascular grafts with advanced mechanical strength from human iPSCs

J Luo, L Qin, L Zhao, L Gui, MW Ellis, Y Huang… - Cell Stem Cell, 2020 - cell.com
Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human
induced pluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts …

Pathogenesis of chronic heart failure: cardiovascular aging, risk factors, comorbidities, and disease modifiers

F Triposkiadis, A Xanthopoulos, J Parissis, J Butler… - Heart failure …, 2022 - Springer
Chronic heart failure (HF) is rare in the young and common in the elderly in the Western
world. HF in the young is usually due to specific causes, predominantly or exclusively …

Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective

N Kakouros, JJ Rade, A Kourliouros… - International journal of …, 2011 - Wiley Online Library
Patients with diabetes mellitus have an increased prevalence of vascular disease.
Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of …

Systems medicine and integrated care to combat chronic noncommunicable diseases

J Bousquet, JM Anto, PJ Sterk, IM Adcock, KF Chung… - Genome medicine, 2011 - Springer
We propose an innovative, integrated, cost-effective health system to combat major non-
communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic …

Role of resident stem cells in vessel formation and arteriosclerosis

L Zhang, S Issa Bhaloo, T Chen, B Zhou… - Circulation research, 2018 - Am Heart Assoc
Vascular, resident stem cells are present in all 3 layers of the vessel wall; they play a role in
vascular formation under physiological conditions and in remodeling in pathological …

Factors contributing to increased platelet reactivity in people with diabetes

DJ Schneider - Diabetes care, 2009 - Am Diabetes Assoc
People with diabetes, particularly those with type 2 diabetes, exhibit increased platelet
reactivity. Hyperglycemia contributes to greater platelet reactivity through direct effects and …

The main determinants of diabetes mellitus vascular complications: endothelial dysfunction and platelet hyperaggregation

A Carrizzo, C Izzo, M Oliveti, A Alfano… - International journal of …, 2018 - mdpi.com
Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy.
In some countries of northern Europe or in North America, it can even affect 6–8% of the …