The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …

Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many
physiological processes, including the innate-and adaptive-immune responses, cell death …

The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

Nuclear factor-κB (NF-κB) is a transcription factor that has crucial roles in inflammation,
immunity, cell proliferation and apoptosis. Activation of NF-κB mainly occurs via IκB kinase …

Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible
transcription in the immune system, has traditionally focused on its role in the initiation of …

It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer
development has been understood. Although much attention has focused on the upstream …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

Complexes formed from the nuclear factor κB (NF-κB) family of transcription factors are
ubiquitously expressed and are induced by a diverse array of stimuli. This results in their …