[PDF][PDF] Evolutionary genetics of the mitochondrial genome: insights from Drosophila

DK Dowling, JN Wolff - Genetics, 2023 - academic.oup.com
Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

Assessing the fitness consequences of mitonuclear interactions in natural populations

GE Hill, JC Havird, DB Sloan, RS Burton… - Biological …, 2019 - Wiley Online Library
Metazoans exist only with a continuous and rich supply of chemical energy from oxidative
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …

[HTML][HTML] Redox stress shortens lifespan through suppression of respiratory complex I in flies with mitonuclear incompatibilities

MF Camus, E Rodriguez, V Kotiadis, H Carter… - Experimental …, 2023 - Elsevier
Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …

Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality

ACY Chiang, J Ježek, P Mu, Y Di, A Klucnika… - Nature …, 2024 - nature.com
Genetic screens have been used extensively to probe interactions between nuclear genes
and their impact on phenotypes. Probing interactions between mitochondrial genes and …

Reconciling the mitonuclear compatibility species concept with rampant mitochondrial introgression

GE Hill - Integrative and Comparative Biology, 2019 - academic.oup.com
The mitonuclear compatibility species concept defines a species as a population that is
genetically isolated from other populations by uniquely coadapted mitochondrial (mt) and …

Sex-specific effects of mitochondrial haplotype on metabolic rate in Drosophila melanogaster support predictions of the Mother's Curse hypothesis

V Nagarajan-Radha, I Aitkenhead… - … of the Royal …, 2020 - royalsocietypublishing.org
Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …

Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity

TS Salminen, PF Vale - Frontiers in Immunology, 2020 - frontiersin.org
Understanding why the response to infection varies between individuals remains one of the
major challenges in immunology and infection biology. A substantial proportion of this …

Mitonuclear genomics and aging

JC Reynolds, CP Bwiza, C Lee - Human genetics, 2020 - Springer
Our cells operate based on two distinct genomes that are enclosed in the nucleus and
mitochondria. The mitochondrial genome presumably originates from endosymbiotic …

Mitochondrial genetic variation as a potential mediator of intraspecific behavioural diversity

JA Brand, F Garcia-Gonzalez, DK Dowling… - Trends in ecology & …, 2024 - cell.com
Mitochondrial genes play an essential role in energy metabolism. Variation in the
mitochondrial DNA (mtDNA) sequence often exists within species, and this variation can …

Challenges and prospects for testing the mother's curse hypothesis

DK Dowling, RE Adrian - Integrative and comparative biology, 2019 - academic.oup.com
Maternal inheritance of mitochondrial DNA (mtDNA) renders selection blind to mutations
whose effects are limited to males. Evolutionary theory predicts this will lead to the …