[PDF][PDF] Evolutionary genetics of the mitochondrial genome: insights from Drosophila
DK Dowling, JN Wolff - Genetics, 2023 - academic.oup.com
Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …
billions of years of evolution inside the eukaryote, mitochondria have retained their own …
Assessing the fitness consequences of mitonuclear interactions in natural populations
Metazoans exist only with a continuous and rich supply of chemical energy from oxidative
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …
[HTML][HTML] Redox stress shortens lifespan through suppression of respiratory complex I in flies with mitonuclear incompatibilities
Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …
Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality
ACY Chiang, J Ježek, P Mu, Y Di, A Klucnika… - Nature …, 2024 - nature.com
Genetic screens have been used extensively to probe interactions between nuclear genes
and their impact on phenotypes. Probing interactions between mitochondrial genes and …
and their impact on phenotypes. Probing interactions between mitochondrial genes and …
Reconciling the mitonuclear compatibility species concept with rampant mitochondrial introgression
GE Hill - Integrative and Comparative Biology, 2019 - academic.oup.com
The mitonuclear compatibility species concept defines a species as a population that is
genetically isolated from other populations by uniquely coadapted mitochondrial (mt) and …
genetically isolated from other populations by uniquely coadapted mitochondrial (mt) and …
Sex-specific effects of mitochondrial haplotype on metabolic rate in Drosophila melanogaster support predictions of the Mother's Curse hypothesis
V Nagarajan-Radha, I Aitkenhead… - … of the Royal …, 2020 - royalsocietypublishing.org
Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …
Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity
Understanding why the response to infection varies between individuals remains one of the
major challenges in immunology and infection biology. A substantial proportion of this …
major challenges in immunology and infection biology. A substantial proportion of this …
Mitonuclear genomics and aging
Our cells operate based on two distinct genomes that are enclosed in the nucleus and
mitochondria. The mitochondrial genome presumably originates from endosymbiotic …
mitochondria. The mitochondrial genome presumably originates from endosymbiotic …
Mitochondrial genetic variation as a potential mediator of intraspecific behavioural diversity
Mitochondrial genes play an essential role in energy metabolism. Variation in the
mitochondrial DNA (mtDNA) sequence often exists within species, and this variation can …
mitochondrial DNA (mtDNA) sequence often exists within species, and this variation can …
Challenges and prospects for testing the mother's curse hypothesis
Maternal inheritance of mitochondrial DNA (mtDNA) renders selection blind to mutations
whose effects are limited to males. Evolutionary theory predicts this will lead to the …
whose effects are limited to males. Evolutionary theory predicts this will lead to the …