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Novel test strategies for in vitro seizure liability assessment
Introduction The increasing incidence of mental illnesses and neurodegenerative diseases
results in a high demand for drugs targeting the central nervous system (CNS). These drugs …
results in a high demand for drugs targeting the central nervous system (CNS). These drugs …
[HTML][HTML] Capturing the third dimension in drug discovery: spatially-resolved tools for interrogation of complex 3D cell models
Abstract Advanced three-dimensional (3D) cell models have proven to be capable of
depicting architectural and microenvironmental features of several tissues. By providing data …
depicting architectural and microenvironmental features of several tissues. By providing data …
Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model
A Charli, H **, V Anantharam, A Kanthasamy… - Neurotoxicology, 2016 - Elsevier
Tebufenpyrad and pyridaben are two agro-chemically important acaricides that function like
the known mitochondrial toxicant rotenone. Although these two compounds have been …
the known mitochondrial toxicant rotenone. Although these two compounds have been …
Release factor inhibiting antimicrobial peptides improve nonstandard amino acid incorporation in wild-type bacterial cells
We report a tunable chemical genetics approach for enhancing genetic code expansion in
different wild-type bacterial strains that employ apidaecin-like, antimicrobial peptides …
different wild-type bacterial strains that employ apidaecin-like, antimicrobial peptides …
Cell encapsulation in gelatin methacryloyl bioinks impairs microscale diffusion properties
Light-assisted bioprinted gelatin methacryloyl (GelMA) constructs have been used for cell-
laden microtissues and organoids. GelMA can be loaded by desired cells, which can …
laden microtissues and organoids. GelMA can be loaded by desired cells, which can …
Spectral unmixing plate reader: high-throughput, high-precision FRET assays in living cells
TM Schaaf, KC Peterson, BD Grant… - … Life Sciences R&D, 2017 - journals.sagepub.com
We have developed a microplate reader that records a complete high-quality fluorescence
emission spectrum on a well-by-well basis under true high-throughput screening (HTS) …
emission spectrum on a well-by-well basis under true high-throughput screening (HTS) …
Update of the scientific opinion on tetrabromobisphenol A (TBBPA) and its derivatives in food
EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2024 - Wiley Online Library
Abstract The European Commission asked EFSA to update its 2011 risk assessment on
tetrabromobisphenol A (TBBPA) and five derivatives in food. Neurotoxicity and …
tetrabromobisphenol A (TBBPA) and five derivatives in food. Neurotoxicity and …
The Role of Ca2+ Imbalance in the Induction of Acute Oxidative Stress and Cytotoxicity in Cultured Rat Cerebellar Granule Cells Challenged with …
E Zieminska, J Lenart, D Diamandakis… - Neurochemical …, 2017 - Springer
Using primary cultures of rat cerebellar granule cells (CGC) we examined the role of calcium
transients induced by tetrabromobisphenol A (TBBPA) in triggering oxidative stress and …
transients induced by tetrabromobisphenol A (TBBPA) in triggering oxidative stress and …
Role of ryanodine and NMDA receptors in tetrabromobisphenol A-induced calcium imbalance and cytotoxicity in primary cultures of rat cerebellar granule cells
E Zieminska, A Stafiej, B Toczylowska, J Albrecht… - Neurotoxicity …, 2015 - Springer
The study assessed the role of ryanodine receptors (RyRs) and NMDA receptors (NMDARs)
in the Ca 2+ transients and cytotoxicity induced in neurons by the brominated flame …
in the Ca 2+ transients and cytotoxicity induced in neurons by the brominated flame …
Fast screening of protein–protein interactions using förster resonance energy transfer (FRET-) based fluorescence plate reader assay in live cells
Protein–protein interactions (PPIs) have great importance for intracellular signal
transduction and sustaining the homeostasis of an organism. Thus, the identification of PPIs …
transduction and sustaining the homeostasis of an organism. Thus, the identification of PPIs …