[PDF][PDF] PROTEIN-TYROSINE KINASES AND THEIR SIGNAL TRANSDUCTION PATHWAYS
Cells modulate their activities in response to signals from their surrounding environment.
Single cell organisms respond mainly to nutrient cues, many of which are able to cross the …
Single cell organisms respond mainly to nutrient cues, many of which are able to cross the …
PI3K/PTEN signaling in angiogenesis and tumorigenesis
BH Jiang, LZ Liu - Advances in cancer research, 2009 - Elsevier
Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
SH2 domains recognize specific phosphopeptide sequences
The discovery that Src homology 2 (SH2) domains provide phosphorylation-dependent and
sequence-specific contacts for assembly of receptor signaling complexes has provided a …
sequence-specific contacts for assembly of receptor signaling complexes has provided a …
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
A new SH2-containing sequence, WC, was isolated by screening cDNA libraries with SH2
representative DNA probes. The WC cDNA is predicted to encode overlap** proteins of …
representative DNA probes. The WC cDNA is predicted to encode overlap** proteins of …
Phosphatidylinositol 3-Kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting
PV Schu, K Takegawa, MJ Fry, JH Stack, MD Waterfield… - Science, 1993 - science.org
The VPS 34 gene product (Vps34p) is required for protein sorting to the lysosome-like
vacuole of the yeast Saccharomyces cerevisiae. Vps34p shares significant sequence …
vacuole of the yeast Saccharomyces cerevisiae. Vps34p shares significant sequence …
Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.
IRS‐1 undergoes rapid tyrosine phosphorylation during insulin stimulation and forms a
stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3 …
stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3 …
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to
specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a …
specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a …
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
M Rozakis-Adcock, J McGlade, G Mbamalu, G Pelicci… - Nature, 1992 - nature.com
THE mammalian shc gene encodes two overlap**, widely expressed proteins of 46 and
52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a …
52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a …
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
G Waksman, D Kominos, SC Robertson, N Pant… - Nature, 1992 - nature.com
Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene
product with two phosphotyrosyl peptides have been determined by X-ray crystallography at …
product with two phosphotyrosyl peptides have been determined by X-ray crystallography at …
Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit
Purified bovine brain phosphatidylinositol 3-kinase (PI3-kinase) is composed of 85 kd and
110 kd subunits. The 85 kd subunit (p85α) lacks PI3-kinase activity and acts as an adaptor …
110 kd subunits. The 85 kd subunit (p85α) lacks PI3-kinase activity and acts as an adaptor …