Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

In analogy to split-protein systems, which rely on the appropriate fragmentation of protein
domains, split aptamers made of two or more short nucleic acid strands have emerged as …

With recent advances in nanotechnology and therapeutic nucleic acids (TNAs), various
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …

Nucleic acids play a central role in all domains of life, either as genetic blueprints or as
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …

Aptamers are exciting smart molecular probes for specific recognition of disease biomarkers.
A number of strategies have been developed to convert target–aptamer binding into …

606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …

Molecular self-assembly has received considerable attention in biomedical fields as a
simple and effective method for develo** biomolecular nanostructures. Self-assembled …

912Nucleic acid nanoparticles (NANPs) have evolved as a new class of therapeutics with
the potential to detect and treat diseases. Despite tremendous advancements in NANP …

With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …