Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

CD4+ T cells can either enhance or inhibit tumour immunity. Although regulatory T cells
have long been known to impede antitumour responses,,,–, other CD4+ T cells have …

The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …

Immune checkpoint blockade therapy has been successful in treating some types of cancer
but has not shown clinical benefits for treating leukaemia. This result suggests that …

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic
influences in human dendritic cell biology and their ability to orchestrate immune responses …

Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune
response to cancer. Thus, induction of their activity is the ultimate aim of all …

Tumor-associated myeloid cells maintain immunosuppressive microenvironments within
tumors. Identification of myeloid-specific receptors to modulate tumor-associated …

▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In
addition, there is increasing evidence that DCs in situ induce antigen-specific …