Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …

Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

The ongoing COVID-19 pandemic has caused significant morbidity and mortality worldwide,
as well as profound effects on society. COVID-19 patients have an increased risk of …

Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

Age-related macular degeneration (AMD) remains a major cause of legal blindness, and
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …

Adeno-associated virus (AAV) based viral vectors are widely used in human gene therapy
and form the basis of approved treatments for several genetic diseases. Immune responses …

C1q is the recognition molecule of the classical pathway of the complement system. By
binding to its targets, such as antigen-bound immunoglobulins or C-reactive protein, C1q …

Background The complement system is an essential component of our innate defense and
plays a vital role in the pathogenesis of many diseases. Assessment of complement …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

Dysregulation of the complement system underlies the pathophysiology of many diseases.
Renewed interest in complement occurred with the recognition that its therapeutic inhibition …