[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …
Metabolic regulation in the induction of trained immunity
AV Ferreira, J Domínguez-Andrés… - Seminars in …, 2024 - Springer
The innate immune system exhibits features of memory, termed trained immunity, which
promote faster and more robust responsiveness to heterologous challenges. Innate immune …
promote faster and more robust responsiveness to heterologous challenges. Innate immune …
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic
immune activation. Whether persistent pathobiont colonization during immune alterations …
immune activation. Whether persistent pathobiont colonization during immune alterations …
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases,
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19
Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although
the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 …
the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 …
Primary nasal influenza infection rewires tissue-scale memory response dynamics
The nasal mucosa is often the initial site of respiratory viral infection, replication, and
transmission. Understanding how infection shapes tissue-scale primary and memory …
transmission. Understanding how infection shapes tissue-scale primary and memory …
How oxygenation shapes immune responses: Emerging roles for physioxia and pathological hypoxia
AS Mirchandani, MA Sanchez-Garcia… - Nature Reviews …, 2024 - nature.com
Most eukaryotes require oxygen for their survival and, with increasing multicellular
complexity, oxygen availability and delivery rates vary across the tissues of complex …
complexity, oxygen availability and delivery rates vary across the tissues of complex …
Translating insights into therapies for Long Covid
AAR Antar, AL Cox - Science translational medicine, 2024 - science.org
Long Covid is defined by a wide range of symptoms that persist after the acute phase of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …
Challenges and opportunities in long COVID research
RE Hamlin, CA Blish - Immunity, 2024 - cell.com
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-
CoV-2 infection but rather have persistent or new symptoms for months to years following …
CoV-2 infection but rather have persistent or new symptoms for months to years following …
BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses
Summary Although the Bacille-Calmette-Guérin (BCG) vaccine is used to prevent
tuberculosis, it also offers protection against a diverse range of non-mycobacterial infections …
tuberculosis, it also offers protection against a diverse range of non-mycobacterial infections …