Critically ill patients and patients with haematological cancer are HIV-negative populations
at high risk of invasive fungal infections. In intensive-care units, candidaemia and intra …

Background Invasive fungal disease (IFD) causes significant morbidity and mortality in
hematologic malignancy patients with high-risk febrile neutropenia (FN). These patients …

Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has
several limitations, mainly associated with its toxicity. Although some lipidic and liposomal …

The uptake of formal AFS programmes has been slow. New initiatives integrating AFS tools
in programmes, and measuring the impacts on patient outcomes are required given such …

One of the main features of the majority of pathogenic fungi is the ability to switch between
different types of morphological forms. These changes include the transition between cells of …

Purpose Patients with persistent or recurrent neutropenic fevers at risk of invasive fungal
disease (IFD) are treated empirically with antifungal therapy (AFT). Early treatment using a …

The human diseases caused by the fungal pathogens Cryptococcus neoformans and
Cryptococcus gattii are associated with high rates of mortality and toxic or cost-prohibitive …

Aim: Mucormycosis is a fungal infection associated with high mortality. Until recently, the
only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a …

The small ubiquitin-related modifier (SUMO) protein is an important component of the post-
translational protein modification systems in eukaryotic cells. It is known to modify hundreds …

Triazole antifungal drugs are widely used for the prophylaxis and treatment of invasive
fungal disease (IFD). Efficacy may depend on attaining minimum effective plasma …