(Z)‐Selective Hydrosilylation and Hydroboration of Terminal Alkynes Enabled by Ruthenium Complexes with an N‐Heterocyclic Carbene Ligand
Y Mutoh, K Yamamoto, Y Mohara… - The Chemical …, 2021 - Wiley Online Library
Abstract Metal‐catalyzed trans‐1, 2‐hydrosilylations and hydroborations of terminal alkynes
that generate synthetically valuable (Z)‐alkenylsilanes and (Z)‐alkenylboranes remain …
that generate synthetically valuable (Z)‐alkenylsilanes and (Z)‐alkenylboranes remain …
Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment
X Huang, Y Chen, W Zhong, Z Liu, H Zhang… - European Journal of …, 2022 - Elsevier
Here, sixteen novel conjugates containing tubulin inhibitor and matrix metalloproteinase
inhibitor was synthesized together with their activity evaluated. Among them, 9e exhibited …
inhibitor was synthesized together with their activity evaluated. Among them, 9e exhibited …
Ionic Reactivity of 2-Isocyanoaryl Thioethers: Access to 2-Halo and 2-Aminobenzothia/Selenazoles
J Dong, J Hu, X Liu, S Sun, L Bao, M Jia… - The Journal of Organic …, 2022 - ACS Publications
An ionic cascade insertion/cyclization reaction of thia-/selena-functionalized arylisocyanides
has been successfully developed for the efficient and practical synthesis of 2 …
has been successfully developed for the efficient and practical synthesis of 2 …
Combretastatin A-4 analogs: Past, present, and future directions
M Mustafa, YA Mostafa, AE Abd Elbaky… - Octahedron Drug …, 2022 - journals.ekb.eg
Microtubules are protein biopolymers created by polymerizing heterodimers of α and β-
tubulins. Microtubule disruption induces G2/M cell cycle arrest and abnormal mitotic spindle …
tubulins. Microtubule disruption induces G2/M cell cycle arrest and abnormal mitotic spindle …
Imaging-guided evaluation of the novel small-molecule benzosuberene tubulin-binding agent KGP265 as a potential therapeutic agent for cancer treatment
Y Guo, H Wang, JL Gerberich, SO Odutola… - Cancers, 2021 - mdpi.com
Simple Summary Vascular-disrupting agents promise significant therapeutic efficacy against
solid tumors by selectively damaging tumor-associated vasculature. Dynamic BLI and …
solid tumors by selectively damaging tumor-associated vasculature. Dynamic BLI and …
Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 …
H Zhang, M Li, X Zhou, L Tang, G Chen… - European Journal of …, 2024 - Elsevier
A series of combretastatin A-4 (CA-4) derivatives were designed and synthesized, which
contain stilbene core structure with different linker, predominantly piperazine derivatives …
contain stilbene core structure with different linker, predominantly piperazine derivatives …
Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agents
X Huang, YS Wang, D Ma, YY Wang, SD Bian… - European Journal of …, 2022 - Elsevier
Hybridization of nitric oxide (NO) donors with known anti-cancer agents have been emerged
as a strategy to achieve improved therapeutic effect and to overcome chemo-resistance in …
as a strategy to achieve improved therapeutic effect and to overcome chemo-resistance in …
Pyrazoline derivatives as tubulin polymerization inhibitors with one hit for Vascular Endothelial Growth Factor Receptor 2 inhibition
B Yang, J Zhou, F Wang, XW Hu, Y Shi - Bioorganic Chemistry, 2021 - Elsevier
In this work, to check the effect of the transposition of the rings in typical patterns, a series of
pyrazoline derivatives 3a-3t bearing the characteristic 3, 4, 5-trimethoxy phenyl and …
pyrazoline derivatives 3a-3t bearing the characteristic 3, 4, 5-trimethoxy phenyl and …
Design, synthesis, and structure–activity relationship studies of 6 H-benzo [b] indeno [1, 2-d] thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit
protein kinase DYRK1A, a target known to have several potential therapeutic applications …
protein kinase DYRK1A, a target known to have several potential therapeutic applications …
Copper-assisted palladium catalyzed the cross-coupling reaction of Alknylalane reagents with 2-Thiobenzo [d] thiazoles via C–S bond cleavage
HL **ao, XY Jia, JX Pu, LR Han, QH Li - Tetrahedron, 2024 - Elsevier
A highly efficient and simple route for the synthesis of 2-alknyl benzo [d] thiazoles has been
developed by palladium and copper catalyzed the cross-coupling reaction of 2-thiobenzo [d] …
developed by palladium and copper catalyzed the cross-coupling reaction of 2-thiobenzo [d] …