α‐enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts
as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix …

Microenvironment plays a crucial role in tumor development and progression. Cancer cells
modulate the tumor microenvironment, which also contribute to resistance to therapy …

Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes
involved in various pathologic and physiologic processes. In cancer, MMPs contribute to …

Pancreatic cancer is the most lethal abdominal malignancy due to its aggressive growth and
rapid development of distant metastases, thus making treatment extremely difficult …

Many investigations of cancer development have pursued the mechanisms by which genetic
mutations stimulate tumor development through activation of oncogenes or loss of tumor …

Extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) is thought to promote
tumor angiogenesis mostly through its protease-inducing function and more recently by its …

The fibroblasts and the myofibroblasts are key players for maintaining skin homeostasis and
for orchestrating physiological tissue repair. The (myo) fibroblasts are embedded in a …

Major determinants that influence negative outcome in cancer patients are the abilities of
cancer cells to resist current therapies and to invade surrounding host tissue, consequently …

In the cornea, the epithelium and the underlying stroma are separated by the basement
membrane and Bowman's layer. The disruption of these anatomical barriers during wound …

Tamoxifen resistance is a major cause of death in patients with recurrent breast cancer.
Current clinical factors can correctly predict therapy response in only half of the treated …