Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the slee**
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

The role of inhibitory circuits in hippocampal memory processing

L Topolnik, S Tamboli - Nature Reviews Neuroscience, 2022 - nature.com
GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease

S Hijazi, AB Smit, RE van Kesteren - Molecular Psychiatry, 2023 - nature.com
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Alternating sources of perisomatic inhibition during behavior

B Dudok, PM Klein, E Hwaun, BR Lee, Z Yao, O Fong… - Neuron, 2021 - cell.com
Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key
GABAergic controllers of hippocampal pyramidal cell output. Although the temporally …

Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression

S Meftah, J Gan - Frontiers in Synaptic Neuroscience, 2023 - frontiersin.org
The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Functions of adult-born neurons in hippocampal memory interference and indexing

SM Miller, A Sahay - Nature neuroscience, 2019 - nature.com
The dentate gyrus–CA3 circuit of the hippocampus is continuously modified by the
integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged …

Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

F **a, BA Richards, MM Tran, SA Josselyn… - Elife, 2017 - elifesciences.org
Following learning, increased coupling between spindle oscillations in the medial prefrontal
cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory …

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization

N Guo, ME Soden, C Herber, MTW Kim, A Besnard… - Nature medicine, 2018 - nature.com
Memories become less precise and generalized over time as memory traces reorganize in
hippocampal–cortical networks. Increased time-dependent loss of memory precision is …

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

T Hainmueller, A Cazala, LW Huang… - Nature …, 2024 - nature.com
The hippocampus is the brain's center for episodic memories. Its subregions, the dentate
gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal …

Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study

R Zomorrodi, G Loheswaran, A Pushparaj, L Lim - Scientific reports, 2019 - nature.com
Transcranial photobiomodulation (tPBM) is the application of low levels of red or near-
infrared (NIR) light to stimulate neural tissues. Here, we administer tPBM in the form of NIR …