Adaptive laboratory evolution principles and applications in industrial biotechnology

M Mavrommati, A Daskalaki, S Papanikolaou… - Biotechnology …, 2022 - Elsevier
Adaptive laboratory evolution (ALE) is an innovative approach for the generation of evolved
microbial strains with desired characteristics, by implementing the rules of natural selection …

Caproic acid production from anaerobic fermentation of organic waste-Pathways and microbial perspective

W Dong, Y Yang, C Liu, J Zhang, J Pan, L Luo… - … and Sustainable Energy …, 2023 - Elsevier
This review aims to provide a holistic synopsis of the current state of the art knowledge on
caproic acid production via anaerobic fermentation from the perspectives of microbes and …

Bioprocess development for muconic acid production from aromatic compounds and lignin

D Salvachúa, CW Johnson, CA Singer, H Rohrer… - Green …, 2018 - pubs.rsc.org
Muconic acid (MA) is a bio-based platform chemical that can be converted into the
commodity petrochemical building blocks adipic acid or terephthalic acid, or used in …

Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid

ME Pyne, JA Bagley, L Narcross, K Kevvai… - Nature …, 2023 - nature.com
Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the
organism's prominence in alcohol fermentation and the suite of sophisticated genetic tools …

Microbial electrosynthesis of acetate powered by intermittent electricity

JS Deutzmann, F Kracke, W Gu… - … Science & Technology, 2022 - ACS Publications
Microbial electrosynthesis (MES) of acetate is a process using electrical energy to reduce
CO2 to acetic acid in an integrated bioelectrochemical system. MES powered by excess …

Medium chain carboxylic acids from complex organic feedstocks by mixed culture fermentation

V De Groof, M Coma, T Arnot, DJ Leak, AB Lanham - Molecules, 2019 - mdpi.com
Environmental pressures caused by population growth and consumerism require the
development of resource recovery from waste, hence a circular economy approach. The …

The damaging effects of short chain fatty acids on Escherichia coli membranes

LA Royce, P Liu, MJ Stebbins, BC Hanson… - Applied microbiology …, 2013 - Springer
Carboxylic acids are an attractive biorenewable chemical. However, like many other
fermentatively produced compounds, they are inhibitory to the biocatalyst. An understanding …

[HTML][HTML] Production of volatile fatty acids through co-digestion of sewage sludge and external organic waste: Effect of substrate proportions and long-term operation

I Owusu-Agyeman, E Plaza, Z Cetecioglu - Waste Management, 2020 - Elsevier
Volatile fatty acids (VFAs) are intermediates of anaerobic digestion with high value and wide
range of usage. Co-digestion of sewage sludge and external organic waste (OW) for VFA …

Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution

R Pereira, ET Mohamed, MS Radi… - Proceedings of the …, 2020 - National Acad Sciences
Toxicity from the external presence or internal production of compounds can reduce the
growth and viability of microbial cell factories and compromise productivity. Aromatic …

Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

R Pereira, Y Wei, E Mohamed, M Radi, C Malina… - Metabolic …, 2019 - Elsevier
Improving the growth phenotypes of microbes in high product concentrations is an essential
design objective in the development of robust cell factories. However, the limited knowledge …