Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation
(PARylation) within seconds after the induction of DNA single-or double-strand breaks …

DNA damage is the prime activator of the enzyme poly (ADP-ribose) polymerase1 (PARP-1)
whose overactivation has been proven to be associated with the pathogenesis of numerous …

The gram-negative facultative anaerobe Bacteroides fragilis (B. fragilis) constitutes an
appreciable proportion of the human gastrointestinal (GI)-tract microbiome. As is typical of …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …

Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …

Glutathione (GSH) is a linchpin of cellular defences in plants and animals with
physiologically-important roles in the protection of cells from biotic and abiotic stresses …

Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple poly (ADP-ribose)
units onto target proteins. Poly (ADP-ribosyl) ation plays a crucial role in a variety of cellular …

Abstract Poly (ADP-ribose)(PAR) is a post-translational modification of proteins and is
synthesised by PAR polymerases (PARPs), which have long been associated with the …