Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …

The interaction between leukemia cells and the bone microenvironment is known to provide
drug resistance in leukemia cells. This phenomenon, called cell adhesion-mediated drug …

There are similarities in the pathophysiologic mechanisms of atherosclerosis, calcific aortic
valve disease (CAVD) and mitral annular calcification (MAC), however, medical treatment to …

Calcified aortic valve disease (CAVD) was previously regarded as a passive process
associated with valve degeneration and calcium deposition. However, recent studies have …

Calcification of the aortic valve is one of the most rapidly increasing pathologies in the aging
population worldwide. Traditionally associated to cardiovascular risk conditions, this …

Cardiac fibrosis represents an enormous health concern as it is prevalent in nearly every
form of cardiovascular disease, the leading cause of death worldwide. Fibrosis is …

Degenerative aortic stenosis is a growing clinical problem owing to the high incidence in an
aging population and its significant morbidity and mortality. Currently, aortic valve …

Introduction: Calcific aortic valve disease (CAVD) is the third most common cardiovascular
disease in aging populations. Despite a growing number of biomarkers having been shown …

BACKGROUND: Aortic valve stenosis (AVS) is the most common valvular disease in the
developed world. AVS involves the progressive fibrocalcific remodeling of the aortic valve …

Background Celecoxib, a selective cyclooxygenase-2 inhibitor, was recently associated with
increased incidence of aortic stenosis and found to produce a valvular calcification risk in …