An in vitro analysis of how lactose modifies the gut microbiota structure and function of adults in a donor-independent manner

J Firrman, LS Liu, K Mahalak, W Hu, K Bittinger… - Frontiers in …, 2023 - frontiersin.org
Introduction Following consumption of milk, lactose, a disaccharide of glucose and
galactose, is hydrolyzed and absorbed in the upper gastrointestinal tract. However …

Glycerol-derived reuterin regulates human intestinal microbiota and metabolites

X Yang, W Liu, X Zhang, M Sun, H Yi, S Liao… - Frontiers in …, 2024 - frontiersin.org
Reuterin, a mixture of different forms of 3-hydroxypropanal (3-HPA), including HPA hydrate
and HPA dimer, is an antimicrobial compound converted from glycerol by Lactobacillus …

Analysis of the ability of capsaicin to modulate the human gut microbiota in vitro

KK Mahalak, J Bobokalonov, J Firrman, R Williams… - Nutrients, 2022 - mdpi.com
Previous studies on capsaicin, the bioactive compound in chili peppers, have shown that it
may have a beneficial effect in vivo when part of a regular diet. These positive health …

Persistence of the Probiotic Lacticaseibacillus rhamnosus Strain GG (LGG) in an In Vitro Model of the Gut Microbiome

KK Mahalak, J Firrman, J Bobokalonov… - International Journal of …, 2022 - mdpi.com
The consumption of probiotics is widely encouraged due to reports of their positive effects on
human health. In particular, Lacticaseibacillus rhamnosus strain GG (LGG) is an approved …

Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model

I Gonza, E Goya-Jorge, C Douny, S Boutaleb… - Food Research …, 2024 - Elsevier
Intestinal fibrosis is a long–term complication of inflammatory bowel diseases (IBD).
Changes in microbial populations have been linked with the onset of fibrosis and some food …

The human colon: Evidence for degenerative changes during aging and the physiological consequences

N Baidoo, GJ Sanger - Neurogastroenterology & Motility, 2024 - Wiley Online Library
Background The incidence of constipation increases among the elderly (> 65 years), while
abdominal pain decreases. Causes include changes in lifestyle (eg, diet and reduced …

Effects of Aspergillus niger biofortification on the microbial community and quality of Baoning vinegar

A Liu, Y Peng, X Ao, W Pan, S Chen, L He, Y Yang… - LWT, 2020 - Elsevier
To further improve the utilization rate of starch in the fermentation of Baoning vinegar, the
effects of Aspergillus niger biofortification on the quality and microbial community of vinegar …

Integrative Analysis of the Gut Microbiota and Metabolome for In Vitro Human Gut Fermentation Modeling

C Wan, K Wu, X Lu, F Fang, Y Li, Y Zhao… - Journal of Agricultural …, 2021 - ACS Publications
This study aimed to find the best in vitro fermentation method by integrative analysis of the
gut microbiota and metabolome. We selected five different media: brain heart infusion broth …

Isotope-coded chemical derivatization method for highly accurately and sensitively quantifying short-chain fatty acids

X Feng, N Liu, Y Yang, S Feng, J Wang… - Journal of Agricultural …, 2022 - ACS Publications
Short-chain fatty acids (SCFAs) are major gut microbiota-derived metabolites, which can
reshape the intestine and regulate gut immunity. The application of conventional GC …

Expression of p16 within myenteric neurons of the aged colon: a potential marker of declining function

A Palmer, S Epton, E Crawley, M Straface… - Frontiers in …, 2021 - frontiersin.org
Human colonic neuromuscular functions decline among the elderly. The aim was to explore
the involvement of senescence. A preliminary PCR study looked for age-dependent …