To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The regular movements of waves and tides are obvious representations of the oceans'
rhythmicity. But the rhythms of marine life span across ecological niches and timescales …

Laboratory mice have provided invaluable insight into mammalian immune systems. Yet the
immune phenotypes of mice bred and maintained in conventional laboratory conditions …

Animals are facing novel 'timescapes' in which the stimuli entraining their daily activity
patterns no longer match historical conditions due to anthropogenic disturbance. However …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …