There has been huge progress in the discovery of targeted cancer therapies in recent years.
However, even for the most successful and impactful cancer drugs which have been …

Proteins are generally detected as biomarkers for tracing or determining various disorders in
organisms. Biomarker proteins can be tracked in samples with various origins and in …

Predicting the effect of missense variations on protein stability and dynamics is important for
understanding their role in diseases, and the link between protein structure and function …

Protein–protein Interactions are involved in most fundamental biological processes, with
disease causing mutations enriched at their interfaces. Here we present mCSM-PPI2, a …

Protein–protein interactions play a crucial role in all cellular functions and biological
processes and mutations leading to their disruption are enriched in many diseases. While a …

Significant efforts have been invested into understanding and predicting the molecular
consequences of mutations in protein coding regions, however nearly all approaches have …

Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …

The ability to identify antigenic determinants of pathogens, or epitopes, is fundamental to
guide rational vaccine development and immunotherapies, which are particularly relevant …

Motivation A lack of accurate computational tools to guide rational mutagenesis has made
affinity maturation a recurrent challenge in antibody (Ab) development. We previously …

Development of new potent, safe drugs to treat Mycobacteria has proven to be challenging,
with limited hit rates of initial screens restricting subsequent development efforts. Despite …