A molecular view of kinetochore assembly and function
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
The molecular basis for centromere identity and function
The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …
meiosis. Although the functional importance of the centromere has been appreciated for …
Methyltransferases: functions and applications
E Abdelraheem, B Thair, RF Varela… - …, 2022 - Wiley Online Library
In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …
methyltransferases and SAM are evaluated. Their structural classification and diversity is …
Comprehensive catalog of currently documented histone modifications
Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …
proteomics have identified a large number of novel histone posttranslational modifications …
N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
Histone variants: key players of chromatin
B Biterge, R Schneider - Cell and tissue research, 2014 - Springer
Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …
Centromere and pericentromere transcription: roles and regulation… in sickness and in health
The chromosomal loci known as centromeres (CEN) mediate the equal distribution of the
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …
[HTML][HTML] Progress in the structural and functional characterization of kinetochores
Highlights•Kinetochores, large macromolecular assemblies, link chromosome to spindle
microtubules.•Kinetochores are crucially required for accurate chromosome segregation in …
microtubules.•Kinetochores are crucially required for accurate chromosome segregation in …
Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells
LJ Luense, X Wang, SB Schon, AH Weller… - Epigenetics & …, 2016 - Springer
Background During the process of spermatogenesis, male germ cells undergo dramatic
chromatin reorganization, whereby most histones are replaced by protamines, as part of the …
chromatin reorganization, whereby most histones are replaced by protamines, as part of the …
Chromatin dynamics during the cell cycle at centromeres
S Müller, G Almouzni - Nature Reviews Genetics, 2017 - nature.com
Centromeric chromatin undergoes major changes in composition and architecture during
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …