Impact of risk factors on early cancer evolution
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …
Squamous cell lung cancer: Current landscape and future therapeutic options
Squamous cell lung cancers (lung squamous cell carcinomas [LUSCs]) are associated with
high mortality and a lack of therapies specific to this disease. Although recurrent molecular …
high mortality and a lack of therapies specific to this disease. Although recurrent molecular …
Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting
Lung cancer remains the leading cause of cancer-related deaths despite recent
breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has …
breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has …
Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer
Tissue-resident memory T (T RM) cells provide immune defense against local infection and
can inhibit cancer progression. However, it is unclear to what extent chronic inflammation …
can inhibit cancer progression. However, it is unclear to what extent chronic inflammation …
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
The KRAS oncoprotein, a critical driver in 33% of lung adenocarcinoma (LUAD), has
remained an elusive clinical target due to its perceived undruggable nature. The …
remained an elusive clinical target due to its perceived undruggable nature. The …
BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
Patients diagnosed with lung squamous cell carcinoma (LUSC) have limited targeted
therapies. We report here the identification and characterisation of BCL11A, as a LUSC …
therapies. We report here the identification and characterisation of BCL11A, as a LUSC …
[HTML][HTML] Mechanisms of DNA damage repair in adult stem cells and implications for cancer formation
Maintenance of genomic integrity in tissue-specific stem cells is critical for tissue
homeostasis and the prevention of deleterious diseases such as cancer. Stem cells are …
homeostasis and the prevention of deleterious diseases such as cancer. Stem cells are …
Enhanced radiation sensitivity, decreased DNA damage repair, and differentiation defects in airway stem cells derived from patients with chronic obstructive …
L Giuranno, JAF Piepers, E Korsten… - Stem Cells …, 2024 - academic.oup.com
Radiation therapy (RT) is a common treatment for lung cancer. Still, it can lead to irreversible
loss of pulmonary function and a significant reduction in quality of life for one-third of …
loss of pulmonary function and a significant reduction in quality of life for one-third of …
Targeting the DNA damage response machinery for lung cancer treatment
KN Venugopala - Pharmaceuticals, 2022 - mdpi.com
Lung cancer is considered the most commonly diagnosed cancer and one of the leading
causes of death globally. Despite the responses from small-cell lung cancer (SCLC) and …
causes of death globally. Despite the responses from small-cell lung cancer (SCLC) and …
[HTML][HTML] Chronic lung diseases: prospects for regeneration and repair
COPD and idiopathic pulmonary fibrosis (IPF) together represent a considerable unmet
medical need, and advances in their treatment lag well behind those of other chronic …
medical need, and advances in their treatment lag well behind those of other chronic …