Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …

Type I (insulin-dependent) diabetes mellitus results from destruction of the beta cells of the
islets of Langerhans, usually leading to absolute insulin deficiency. Although some patients …

Background Autoantibodies to islet-cell cytoplasm (ICA) and glutamic acid decarboxylase
(GADA) can occur in apparently typical, non-insulin dependent diabetes mellitus (type 2) …

With the development of an insulin autoantibody (IAA) assay performed in 96-well filtration
plates, we have evaluated prospectively the development of IAA in NOD mice (from 4 weeks …

Strategies for assessing risk of progression to IDDM, based on single and combined
autoantibody measurement, were evaluated in 2,855 schoolchildren (median age 11.4 …

OBJECTIVE—The aim of the present study was to define heterogeneity of adult-onset
autoimmune diabetes based on characterization of GAD antibodies (GADAs). RESEARCH …

Background: Autoantibodies to glutamic acid decarboxylase (GAD-A) are present in type 1
diabetes and stiff man syndrome (SMS), and have also been reported in cerebellar ataxia …

Aims/hypothesis Islet autoantibodies are important in diabetes classification and risk
assessment, and as endpoints in observational studies. The Diabetes Autoantibody …

On the basis of the positive outcome of animal experiments, several large placebo-
controlled trials are underway and aiming for the first time at the prevention of an immune …

An unselected population of 755 siblings of children with insulin-dependent diabetes
mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies …