NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …

In the context of OA disease, NF-κB transcription factors can be triggered by a host of stress-
related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM …

Activation of nuclear factor (NF)-κB, one of the most investigated transcription factors, has
been found to control multiple cellular processes in cancer including inflammation …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

The inflammasome adapter ASC links activated inflammasome sensors to the effector
molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic …

The understanding of the impact of the non-canonical NF-κB (nuclear factor kappa-light-
chain-enhancer of activated B cells) pathway in several human diseases including …

Appropriate development of stratified, squamous, keratinizing epithelia, such as the
epidermis and oral epithelia, generates an outer protective permeability barrier that prevents …

Abstract IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two
kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating …

The inflammasomes are multiprotein complexes that activate caspase-1 in response to
infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report …

Canonical and noncanonical nuclear factor κB (NF-κB) signaling are the two basic pathways
responsible for the release of NF-κB dimers from their inhibitors. Enhanced NF-κB signaling …