Virus infections induce a proinflammatory response including expression of cytokines and
chemokines. The subsequent leukocyte recruitment and antiviral effector functions …

The rate of progression of HIV disease may be substantially different among HIV-infected
individuals. Following infection of the host with any virus, the delicate balance between virus …

Characterization of the immune responses induced in the initial stages of human
immunodeficiency virus type 1 (HIV-1) infection is of critical importance for an understanding …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

The life cycle of human immunodeficiency virus type 1 (HIV-1) is intricately related to the
activation state of the host cells supporting viral replication. Although cellular activation is …

T cell activation levels in HIV infection are predictive of AIDS progression. We searched for
the immunological correlates of protection against disease progression by studying the early …

The HIV-1 accessory gene product Vpr can influence viral pathogenesis by affecting viral
replication as well as host cell transcription and proliferation. We have investigated the …

Symptoms of T cell hyperactivation shape the course and outcome of HIV-1 infection, but the
mechanism (s) underlying this chronic immune activation are not well understood. We find …

The HIV-1 infection in humans induces an early cellular immune response to react to the
viral proteins with a cytotoxic T cell (CTL) response that fails to inhibit virus replication and …

Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of
immune hyperactivation in patients. Infection of human peripheral blood lymphocytes with …