Although mitochondrial contributions to cancer have been recognised for approximately a
century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome …

Melanoma as the most major skin malignancy has attracted much attention, so far. Although
a successful therapeutic strategy requires an accurate understanding of the precise …

Cancer is an important cause of morbidity and mortality worldwide. Advances in research on
the biology of cancer revealed alterations in several key pathways underlying tumorigenesis …

Over the past few decades, research on reactive oxygen species (ROS) has revealed their
critical role in the initiation and progression of cancer by virtue of various transcription …

Increased glycolysis is one of the key metabolic hallmarks of cancer cells. However, the
roles of lncRNAs in energy metabolism and cancer metastasis remain unclear. Here, the …

Platelet‑derived growth factor (PDGF) is a potent mitogen and chemoattractant that serves a
role in the development of several types of solid cancer, and abnormal PDGF activity has …

A major contributing factor in triple-negative breast cancer progression is its ability to evade
immune surveillance. One mechanism for this immunosuppression is through ribosomal …

Background Anoikis resistance plays a critical role in the tumor metastasis by allowing
survival of cancer cells in the systemic circulation. We previously showed that long non …

Paclitaxel is a first line chemotherapeutic agent for the patients with metastatic breast
cancer. But inherited or acquired resistance to paclitaxel leads to poor response rates in a …

Abstract Approximately 15-20% of breast carcinomas exhibit human epidermal growth factor
receptor (HER2) protein overexpression. HER2-positive breast cancer (BC) is a …