G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

The discovery and clinical implementation of modulators of adenosine, P2Y and P2X
receptors (comprising nineteen subtypes) have progressed dramatically in∼ 50 years since …

G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible
conformational states and in dynamic equilibrium between monomers and higher-order …

Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First
generation or typical antipsychotics such as haloperidol and second generation or atypical …

Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing
prevalence presents treatment challenges. Despite a better understanding of the disease …

G protein-coupled receptors (GPCRs) are the largest human membrane protein family that
transduce extracellular signals into cellular responses. They are major pharmacological …

Dopamine D2-like receptors (D2R, D3R, and D4R) control diverse physiological and
behavioral functions and are important targets for the treatment of a variety of …

Innovation of cancer therapy has received a dramatic acceleration over the last fifteen years
thanks to the introduction of the novel immune checkpoint inhibitors (ICI). On the other hand …

Molecular dynamic (MD) simulations have become a common tool to study the pathway of
ligand entry to the orthosteric binding site of G protein-coupled receptors. Here, we have …