Plant defensins form a family of proteins with a broad spectrum of protective activities
against fungi, bacteria, and insects. Furthermore, some plant defensins have revealed …

A survey, primarily based on work in the authors' laboratory during the last 10 years, is
provided of recent developments in NMR studies of exchange processes involving protein …

Protein function originates from a cooperation of structural rigidity, dynamics at different
timescales, and allostery. However, how these three pillars of protein function are integrated …

The high-fidelity (HF1), hyper-accurate (Hypa), and evolved (Evo) variants of the CRISPR-
associated protein 9 (Cas9) endonuclease are critical tools to mitigate off-target effects in the …

The phenomenon of chemical or conformational exchange in NMR spectroscopy has
enabled detailed characterization of time-dependent aspects of biomolecular function …

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin
signaling pathways, making it a highly attractive target for the treatment of type II diabetes …

Allostery is a major driver of biological processes requiring coordination. Thus, it is one of
the most fundamental and remarkable phenomena in nature, and there is motivation to …

Conventional understanding of how enzymes function strongly emphasizes the role of
structure. However, increasing evidence clearly indicates that enzymes do not remain fixed …

Allostery is a ubiquitous biological mechanism in which a distant binding site is coupled to
and drastically alters the function of a catalytic site in a protein. Allostery provides a high …

Protein folding is a highly complex process proceeding through a number of disordered and
partially folded nonnative states with various degrees of structural organization. These …