The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

The microtubule-binding interface of the kinetochore is of central importance in chromosome
segregation. Although kinetochore components that stabilize, translocate on, and affect the …

Changes in DNA copy number, whether confined to specific genes or affecting whole
chromosomes, have been identified as causes of diseases and developmental …

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of
subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 …

The centromere is a chromosomal locus that ensures delivery of one copy of each
chromosome to each daughter at cell division. Efforts to understand the nature and …